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With normal liver and thyroid function tests, lovastatin was discontinued, but the patient's creatine phosphokinase (CPK) levels remained elevated (all CPK-MM) and the patient's symptoms persisted. Similarly, lovastatin labeling recommends that therapy begin at 10 mg/day and not exceed 20 mg/day when prescribed with cyclosporine. MANAGEMENT: The benefits of the use of atorvastatin, lovastatin, simvastatin, and red yeast rice (which contains lovastatin) in patients receiving cyclosporine should be carefully weighed against the potential risks. However, elderly patients are more likely to have age-related kidney problems, which may require an adjustment in the dose for patients receiving lovastatin extended-release tablets. In a ten-subject study, coadministration of diltiazem (120 mg bid, diltiazem SR) with lovastatin resulted in 3- to 4-fold increase in mean lovastatin AUC and Cmax versus lovastatin alone; no change in pravastatin AUC and Cmax was observed during diltiazem coadministration.

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